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Researchers have found a switch that seems to turn on a mouse’s predatory instincts. When certain parts of the rodents’ brains were stimulated with light, mice displayed a complex array of hunting activities.
Predatory behaviours such as grabbing and biting are familiar to fans of nature documentaries, but the brain circuits involved remain a mystery. Previous research found that the central amygdala, an almond-shaped area of the brain involved in producing emotions including fear, was activated when rats hunt. Researchers wanted to know whether the amygdala itself controls hunting behaviours, and a study published on 12 January in Cell suggests that it does.
To activate the central amygdala in mice, Ivan de Araujo, a neurobiologist at Yale University in New Haven, Connecticut, and his colleagues used a technique called optogenetics. First, they infected the mice with a virus that made the neurons in their brains sensitive to blue light. Then, the researchers used a tiny optic fibre to shine a blue laser on the amygdala. This prompted the animals to tense their jaw and neck muscles. The behaviour didn’t occur when the researchers stimulated other parts of the brain.
When the laser was on, the mice hunted just about everything placed in their paths, from edible treats such as crickets to non-food items like bottle caps. The researchers observed the same activity when they triggered the amygdala with chemogenetics, a similar technique that stimulates neurons with molecules rather than light. The hunting and feeding behaviours even happened when there was nothing to hunt. When mice in empty cages had their amygdalas activated, they stopped whatever they were doing, positioned their front legs as if they were holding food and moved their mouths as if they were chewing.
Predatory: adj. 掠食的。
Rodent: n. 啮齿动物[如老鼠、兔子]。
An array of: 一排,一批,大量。
Amygdala: n.[解剖] 杏仁核。
Optogenetics: 光遗传学。
Edible: adj. 可食用的;n. 食品,食物。
Molecules: n.[化学]分子,微粒。
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